微電極細胞電訊號記錄分析系統_Physiological electrical signal

放置地點
慈濟大學中央校區勤耕樓 D921  教學研究輔助中心

儀器介紹與應用
以記錄腦薄片海馬迴興奮性突觸後電位為主，運用電流刺激以及變換各種不同的刺激條件，或是藥物處理，來誘發海馬迴突觸傳導效能之長期增益 (long-term potentiation)與長期抑制 (long-term depression) 的效應，再搭配藥理的運用，則能夠讓研究者更仔細的探討各種生理反應，或是各種藥物之機轉。

Focusing primarily on recording excitatory postsynaptic potentials (EPSPs) in hippocampal slices, the effects of long-term potentiation (LTP) and long-term depression (LTD) of hippocampal synaptic transmission can be induced by using electrical stimulation and varying different stimulation parameters, or by applying pharmacological agents. The combination with pharmacological manipulation further allows researchers to examine in greater detail the mechanisms of various physiological responses or the mechanisms of action of different drugs.

成果發表

  1. Attenuation of HECT-E3 ligase expression rescued memory deficits in 3xTg-AD mice
    Pavithra Suresh, Sureka Jasmin, Yun Yen, Hao-Jen Hsu, Peeraporn Varinthra, Tanita Pairojana, Chien-Chang Chen and Ingrid Y. Liu
    Front. Aging Neurosci., 29 July 2022 Volume 14 - 2022; https://doi.org/10.3389/fnagi.2022.916904

  2. Behavioral and Synaptic Phenotypes of Female Prdx6−/− Micel
    Tanita Pairojana, Sarayut Phasuk, Pavithra Suresh, Ingrid Y Liu
    Antioxidants (Basel). 2022 Jun 19;11(6):1201. doi: 10.3390/antiox11061201.

  3. Lack of the peroxiredoxin 6 gene causes impaired spatial memory and abnormal synaptic plasticity
    Sarayut Phasuk, Sureka Jasmin, Tanita Pairojana, Hsueh-Kai Chang, Kai-Chi Liang & Ingrid Y. Liu
    Molecular Brain; 2021 Apr 19; 14(1):72. doi: 10.1186/s13041-021-00779-6

  4. The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice.
    Peeraporn Varinthra, Kiruthika Ganesan, Shun-Ping Huang, Supin Chompoopong, Chatchakorn Eurtivong, Pavithra Suresh, Zhi-Hong Wen, Ingrid Y Liu
    Frontiers in Aging Neuroscience; 2021 Feb 3;13:615079. doi: 10.3389/fnagi.2021.615079