正立共軛焦顯微鏡_NIKON C2si+

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慈濟大學中央校區勤耕樓 D328  生物影像實驗室

儀器介紹

  • C2+利用pixel shift correction mechanism，修正傳統confocal system在Fast bi-directional scanning掃瞄模式下的像素位移，達到高速擷取目的。
  • 搭配NIS-Elements影像操控軟體，可直觀操作Nikon顯微鏡與第三方硬體，協助完成各式各樣的實驗需求。
  • 高效率掃瞄頭搭配訊號感測器。
  • 高清晰度穿透式DIC影像、運用特殊奈米鍍膜技術Nano Crystal Coat technology，光線穿透率大大提升。
  • C2-DUS Spectral Detector Unit : 32支可調校PMT感測器，一次  掃瞄可涵蓋320nm波長範圍的訊號，波長解析度高達2.5nm 。
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儀器規格

  • 物鏡：10X (水鏡)、10X、20X、40X、40X (油鏡)、60X (油鏡)
  • Laser：405nm、488nm、561nm、640nm

 

成果發表

  1. The Role of Activating Transcription Factor 3 in Metformin’s Alleviation of Gastrointestinal Injury Induced by Restraint Stress in Mice
    Bijaya Siwakoti, Te-Sheng Lien, You-Yen Lin, Subhashree Pethaperumal, Shih-Che Hung, Der-Shan Sun, Ching-Feng Cheng andHsin-Hou Chang
    Int. J. Mol. Sci. 2023, 24(13), 10995; https://doi.org/10.3390/ijms241310995
  2. Simulation of Hemorrhage Pathogenesis in Mice through Dual Stimulation with Dengue Envelope Protein Domain III-Coated Nanoparticles and Antiplatelet Antibody
    Te-Sheng Lien, Der-Shan Sun, Wen-Sheng Wu and Hsin-Hou Chang
    Int. J. Mol. Sci. 2023, 24(11), 9270; https://doi.org/10.3390/ijms24119270
  3. Restraint Stress-Induced Immunosuppression Is Associated with Concurrent Macrophage Pyroptosis Cell Death in Mice
    Chi-Cheng Li, Rina Munalisa, Hsuan-Yun Lee, Te-Sheng Lien, Hao Chan, Shih-Che Hung, Der-Shan Sun , Ching-Feng Cheng and Hsin-Hou Chang
    Int. J. Mol. Sci. 2023, 24(16), 12877; https://doi.org/10.3390/ijms241612877
  4. Restraint stress‑associated gastrointestinal injury and implications from the Evans blue‑fed restraint stress mouse model
    Der‑Shan Sun, Te‑Sheng Lien, Hsin‑Hou Chang
    Tzu Chi Medical Journal 36(1):p 23-29, Jan–Mar 2024. DOI: 10.4103/tcmj.tcmj_101_23
  5. Effect of Size and Concentration of Copper Nanoparticles on the Antimicrobial Activity in Escherichia coli through Multiple Mechanisms
    Meng-Jiun Lai, Yue-Wern Huang, Hsuan-Chun Chen, Li-I Tsao, Chih-Fang Chang Chien,Bhaskar Singh and Betty Revon Liu
    Nanomaterials 2022, 12(21), 3715; https://doi.org/10.3390/nano12213715
  6. Nanodiamond-induced thrombocytopenia in mice involves P-selectin-dependent Nlrp3 inflammasome-mediated platelet aggregation and pyroptosis
    Shih-Che Hung, Lu-Chu Ke, Te-Sheng Lien, Hsuan-Shun Huang, Der-Shan Sun Chia-Liang Cheng and Hsin-Hou Chang
    Front. Immunol., 04 April 2022. doi:org/10.3389/fimmu.2022.806686
  7. Activating Transcription Factor 3 Protects against Restraint Stress-Induced Gastrointestinal Injury in Mice
    Dun-Jie Chuang, Subhashree Pethaperumal, Bijaya Siwakoti, Hung-Jen Chien, Ching-Feng Cheng, Shih-Che Hung, Te-Sheng Lien, Der-Shan Sun and Hsin-Hou Chang
    Cells. 2021 Dec 14;10(12):3530. doi: 10.3390/cells10123530.
  8. Intermittent Hypoxia Induces Autophagy to Protect Cardiomyocytes From Endoplasmic Reticulum Stress and Apoptosis
    Jui-Chih Chang, Wei-Fen Hu, Wen-Sen Lee, Jian-Hong Lin, Pei-Ching Ting, Huai-Ren Chang, Kun-Ruey Shieh, Tsung-I Chen, Kun-Ta Yang
    Front Physiol. 2019 Aug 7;10:995.doi: 10.3389/fphys.2019.00995. eCollection 2019.
  9. Dengue Virus Envelope Protein Domain III Induces Nlrp3 Inflammasome-Dependent NETosis-Mediated Inflammation in Mice
    Te-Sheng Lien, Der-Shan Sun, Shih-Che Hung, Wen-Sheng Wu, Hsin-Hou Chang
    Front Immunol.; 2021 Mar 17;12:618577. doi: 10.3389/fimmu.2021.618577. eCollection 2021.
  10. PKCδ mediates mitochondrial ROS generation and oxidation of HSP60 to relieve RKIP inhibition on MAPK pathway for HCC progression
    Jaya Prakash Mandal, Chiou-Nan Shiue, Yen-Cheng Chen, Ming-Che Lee, Hsueh-Hui Yang, Hsin-Hou Chang, Chi-Tan Hu, Pei-Chen Liao, Lin-Ching Hui, Ren-In You, Wen-Sheng Wu
    Free Radic Biol Med.; 2021 Feb 1;163:69-87. doi: 10.1016/j.freeradbiomed.2020.12.003
  11. Enhanced contextual fear memory in peroxiredoxin 6 knockout mice is associated with hyperactivation of MAPK signaling pathway.
    Sarayut Phasuk, Tanita Pairojana, Pavithra Suresh, Chee-Hing Yang, Sittiruk Roytrakul, Shun-Ping Huang, Chien-Chang Chen, Narawut Pakaprot, Supin Chompoopong, Sutisa Nudmamud-Thanoi, Ingrid Y Liu
    Molecular Brain; 2021 Feb 25;14(1):42. doi: 10.1186/s13041-021-00754-1
  12.  Visible-Light-Responsive Antibacterial Property of Boron-Doped Titania Films
    Ming-Show Wong, Man-Ting Sun, Der-Shan Sun and Hsin-Hou Chang
    Catalysts 2020, 10(11), 1349; https://doi.org/10.3390/catal10111349
  13. Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice
    Yu-Yi Ho, Der-Shan Sun, Hsin-Hou Chang
    Int J Mol Sci.; 2020 Sep 25;21(19):7082. doi: 10.3390/ijms21197082.
  14. Palmitic Acid Methyl Ester Induces G2/M Arrest in Human Bone Marrow-Derived Mesenchymal Stem Cells via the p53/p21 Pathway
    Jian Hong Lin, Pei Ching Ting, Wen Sen Lee, Hung Wen Chiu, Chun An Chien, Chin Hung Liu, Li Yi Sun, Kun Ta Yang
    Stem Cells Int.; 2019 Dec 1;2019:7606238. doi: 10.1155/2019/7606238.
  15. Thioacetamide-induced liver damage and thrombocytopenia is associated with induction of antiplatelet autoantibody in mice
    You-Yen Lin, Chi-Tan Hu, Der-Shan Sun, Te-Sheng Lien & Hsin-Hou Chang
    Scientific Reports; 2019 Nov 25;9(1):17497. doi: 10.1038/s41598-019-53977-7.
  16. Raman spectroscopy on live mouse early embryo while it continues to develop into blastocyst in vitro
    Elena Perevedentseva, Alexander Krivokharchenko, Artashes V. Karmenyan, Hsin-Hou Chang & Chia-Liang Cheng
    Scientific Reports; 2019 Apr 29;9(1):6636. doi: 10.1038/s41598-019-42958-5.