雷射共軛焦正立顯微鏡_Zeiss LSM 900

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慈濟大學中央校區勤耕樓 E307  生物醫學研究核心設施

儀器介紹與應用

  • 高解析: 提升2倍的解析度 (逼近超高解析度SIM的解析能力)
  • 高速掃描: 超高速掃描每秒47幅 (同時增加4~8倍的靈敏度)
  • 高靈敏度: 高感度32個磷砷化鎵GaAsP感測器陣列 (超越共軛焦顯微鏡的極限)
  • 玻片樣品螢光拍攝
  • 組織樣品大面積拼圖
  • 3-D影像 (Z-stack)
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儀器規格

  • 物鏡: 10X. 20X. 40X (油鏡). 63X (油鏡)
  • Laser: 405, 488, 561, 640 nm
  • 電動載物台

成果發表

  1. Protective effects of compound M01 on retinal ganglion cells in experimental anterior ischemic optic neuropathy by inhibiting TXNIP/NLRP3 inflammasome pathway
    Jia-Ying Chien, Jhih-Wei Ciou, Yun Yen, Shun-Ping Huang
    Biomed Pharmacother. 2023 Dec 31:169:115861. doi: 10.1016/j.biopha.2023.115861.
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  2. Pinostrobin modulates FOXO3 expression, nuclear localization, and exerts antileukemic effects in AML cells and zebrafish xenografts
    Pei-Yi Chen , Ching-Yen Lin , Chia-Ling Wu , Pei Ying Keak , Je-Wen Liou , Wan-Yun Gao , Liang-In Lin , Jui-Hung Yen
    Chemico-Biological Interactions 2023;110729. doi: 10.1016/j.cbi.2023.110729
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  3. Cell Cycle Regulation by NF-YC in Drosophila Eye Imaginal Disc: Implications for Synchronization in the Non-Proliferative Region
    Anthony Avellino, Chen-Huan Peng, and Ming-Der Lin
    Int. J. Mol. Sci. 2023, 24(15), 12203. https://doi.org/10.3390/ijms241512203
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  4. Drosophila Phosphatase of Regenerating Liver Is Critical for Photoreceptor Cell Polarity and Survival during Retinal Development
    Shu-Fen Chen, Hsin-Lun Hsien, Ting-Fang Wang and Ming-Der Lin
    Int. J. Mol. Sci. 2023, 24, 11501. https://doi.org/ 10.3390/ijms241411501
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  5. The Effects of Lycium chinense, Cuscuta chinensis, Senna tora, Ophiopogon japonicus, and Dendrobium nobile Decoction on a Dry Eye Mouse Model
    Cheng-Chan Yang,Jia-Ying Chien,Yu-Yau Chou,Jhih-Wei Ciou and Shun-Ping Huang
    Medicina 2022, 58(8), 1134; https://doi.org/10.3390/medicina58081134
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  6. The Protective Effects of n-Butylidenephthalide on Retinal Ganglion Cells during Ischemic Injury
    Yu-Yau Chou ,Jia-Ying Chien ,Jhih-Wei Ciou and Shun-Ping Huang
    Int. J. Mol. Sci. 2022, 23(4), 2095. doi:org/10.3390/ijms23042095.
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  7. The Effects of Two Nrf2 Activators, Bardoxolone Methyl and Omaveloxolone, on Retinal Ganglion Cell Survival during Ischemic Optic Neuropathy
    Jia-Ying Chien,Yu-Yau Chou,Jhih-Wei Ciou,Fang-Yun Liu and Shun-Ping Huang
    Antioxidants; 2021, 10(9), 1466; https://doi.org/10.3390/antiox10091466
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  8. Protective Effects of Oroxylin A on Retinal Ganglion Cells in Experimental Model of Anterior Ischemic Optic Neuropathy
    Jia-Ying Chien, Shu-Fang Lin, Yu-Yau Chou, Chi-Ying F Huang, Shun-Ping Huang
    Antioxidants; 2021 Jun 3;10(6):902. doi: 10.3390/antiox10060902.